The role of long non-coding RNA H19 in musculoskeletal system: A new player in an old game

doi:10.1016/j.yexcr.2017.09.007

Review

. 2017 Nov 15;360(2):61-65.

doi: 10.1016/j.yexcr.2017.09.007. Epub 2017 Sep 7.

The role of long non-coding RNA H19 in musculoskeletal system: A new player in an old game

Yang Liu¹, Gang Li², Jin-Fang Zhang³

Affiliations

¹ Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
² Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Stem Cells and Regenerative Medicine Laboratory, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China. Electronic address: gangli@cuhk.edu.hk.
³ Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Stem Cells and Regenerative Medicine Laboratory, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China. Electronic address: zhangjf06@cuhk.edu.hk.

PMID: 28890290
DOI: 10.1016/j.yexcr.2017.09.007

Review

The role of long non-coding RNA H19 in musculoskeletal system: A new player in an old game

Yang Liu et al. Exp Cell Res. 2017.

. 2017 Nov 15;360(2):61-65.

doi: 10.1016/j.yexcr.2017.09.007. Epub 2017 Sep 7.

Authors

Yang Liu¹, Gang Li², Jin-Fang Zhang³

Affiliations

¹ Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
² Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Stem Cells and Regenerative Medicine Laboratory, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China. Electronic address: gangli@cuhk.edu.hk.
³ Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Stem Cells and Regenerative Medicine Laboratory, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China. Electronic address: zhangjf06@cuhk.edu.hk.

PMID: 28890290
DOI: 10.1016/j.yexcr.2017.09.007

Abstract

The long non-coding RNAs (lncRNAs) have gained much attention due to its essential roles in molecular regulation. As one of the classic lncRNAs, H19 is strongly expressed during embryogenesis and plays a crucial biological function during development. Mesenchymal stem cells (MSCs) are an ideal cell source for tissue engineering in musculoskeletal system as they own the multi-differentiation ability towards osteogenesis, adipogenesis, tenogenesis or chondrogenesis. In recent years, many studies have been found in the field of H19 mediated cellular differentiation of MSCs. Here, we summarized the current understanding of H19 during multi-differentiation of MSCs and its application in tissue regeneration of musculoskeletal system. Particularly, its molecular regulation and biological function during the multi-differentiation were also discussed.

Keywords: Cellular differentiation; H19; Long non-coding RNA; Musculoskeletal system.

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The role of long non-coding RNA H19 in musculoskeletal system: A new player in an old game

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The role of long non-coding RNA H19 in musculoskeletal system: A new player in an old game

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