Abstract
Cholecystectomy has long been regarded as a safe procedure with no deleterious influence on the body. However, recent studies provide clues that link cholecystectomy to a high risk for metabolic syndrome (MetS). In the present review, we describe the epidemiologic evidence that links cholecystectomy to MetS. Various components of MetS are investigated, including visceral obesity, dyslipidemia, elevated blood pressure, impaired fasting glucose, and insulin resistance. The possible mechanisms that associate cholecystectomy with MetS are discussed on the basis of experimental studies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bile Acids and Salts / metabolism
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Cholecystectomy / adverse effects*
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Cholelithiasis / epidemiology
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Cholelithiasis / etiology
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Cholelithiasis / metabolism
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Cholelithiasis / physiopathology
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Comorbidity
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Dyslipidemias / epidemiology
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Dyslipidemias / etiology
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Dyslipidemias / metabolism
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Dyslipidemias / physiopathology
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Energy Metabolism
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Gallbladder / metabolism
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Gallbladder / physiopathology
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Glucose Intolerance / epidemiology
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Glucose Intolerance / etiology
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Glucose Intolerance / metabolism
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Glucose Intolerance / physiopathology
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Humans
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Insulin Resistance
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Liver / metabolism
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Liver / physiopathology
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Metabolic Syndrome / epidemiology
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Metabolic Syndrome / etiology*
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Metabolic Syndrome / metabolism
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Metabolic Syndrome / physiopathology
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Models, Biological*
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Non-alcoholic Fatty Liver Disease / epidemiology
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Non-alcoholic Fatty Liver Disease / etiology
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Non-alcoholic Fatty Liver Disease / metabolism
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Non-alcoholic Fatty Liver Disease / physiopathology
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Obesity, Abdominal / epidemiology
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Obesity, Abdominal / etiology
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Obesity, Abdominal / metabolism
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Obesity, Abdominal / physiopathology
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Postoperative Complications / epidemiology
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Postoperative Complications / etiology*
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Postoperative Complications / metabolism
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Postoperative Complications / physiopathology
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Risk Factors