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Review
. 2017 Dec 7;12(12):2046-2049.
doi: 10.2215/CJN.07630717. Epub 2017 Sep 11.

Drug-Induced Acute Interstitial Nephritis

Dennis G Moledina  1 , Mark A Perazella  1   2
Affiliations
Review

Drug-Induced Acute Interstitial Nephritis

Dennis G Moledina et al. Clin J Am Soc Nephrol. .
No abstract available

Keywords: Acute; Interstitial; Kidney Tubular Necrosis; Nephritis; acute interstitial nephritis; acute kidney injury; corticosteroids; drugs; kidney biopsy.

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Figures

Figure 1.
Figure 1.
Algorithm for management of drug-induced acute interstitial nephritis. *In patients where kidney biopsy cannot be performed, the decision to start a trial of empirical steroids can be considered on a patient-by-patient basis. An ultrasound showing small kidneys usually indicates advanced fibrosis and unlikely benefit from corticosteroid use. Unfortunately, there are currently no tests that can be recommended to replace biopsy to establish DI-AIN diagnosis. AIN, acute interstitial nephritis; AKD, acute kidney disease; AKI, acute kidney injury; DI-AIN, drug-induced acute interstitial nephritis; IF, interstitial fibrosis; WBC, white blood cell.
See this image and copyright information in PMC

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References

    1. Perazella MA, Markowitz GS: Drug-induced acute interstitial nephritis. Nat Rev Nephrol 6: 461–470, 2010 - PubMed
    1. Perazella MA: Clinical approach to diagnosing acute and chronic tubulointerstitial disease. Adv Chronic Kidney Dis 24: 57–63, 2017 - PubMed
    1. Chu R, Li C, Wang S, Zou W, Liu G, Yang L: Assessment of KDIGO definitions in patients with histopathologic evidence of acute renal disease. Clin J Am Soc Nephrol 9: 1175–1182, 2014 - PMC - PubMed
    1. Clarkson MR, Giblin L, O’Connell FP, O’Kelly P, Walshe JJ, Conlon P, O’Meara Y, Dormon A, Campbell E, Donohoe J: Acute interstitial nephritis: Clinical features and response to corticosteroid therapy. Nephrol Dial Transplant 19: 2778–2783, 2004 - PubMed
    1. González E, Gutiérrez E, Galeano C, Chevia C, de Sequera P, Bernis C, Parra EG, Delgado R, Sanz M, Ortiz M, Goicoechea M, Quereda C, Olea T, Bouarich H, Hernández Y, Segovia B, Praga M; Grupo Madrileño De Nefritis Intersticiales: Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int 73: 940–946, 2008 - PubMed