Tumour viruses and innate immunity

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):20160267. doi: 10.1098/rstb.2016.0267.

Abstract

Host cells sense viral infection through pattern recognition receptors (PRRs), which detect pathogen-associated molecular patterns (PAMPs) and stimulate an innate immune response. PRRs are localized to several different cellular compartments and are stimulated by viral proteins and nucleic acids. PRR activation initiates signal transduction events that ultimately result in an inflammatory response. Human tumour viruses, which include Kaposi's sarcoma-associated herpesvirus, Epstein-Barr virus, human papillomavirus, hepatitis C virus, hepatitis B virus, human T-cell lymphotropic virus type 1 and Merkel cell polyomavirus, are detected by several different PRRs. These viruses engage in a variety of mechanisms to evade the innate immune response, including downregulating PRRs, inhibiting PRR signalling, and disrupting the activation of transcription factors critical for mediating the inflammatory response, among others. This review will describe tumour virus PAMPs and the PRRs responsible for detecting viral infection, PRR signalling pathways, and the mechanisms by which tumour viruses evade the host innate immune system.This article is part of the themed issue 'Human oncogenic viruses'.

Keywords: EBV; HCV; HPV; KSHV; innate immunity; tumour virus.

Publication types

  • Review

MeSH terms

  • Humans
  • Immunity, Innate*
  • Oncogenic Viruses / physiology*
  • Pathogen-Associated Molecular Pattern Molecules / metabolism*
  • Receptors, Pattern Recognition / genetics
  • Receptors, Pattern Recognition / metabolism*
  • Signal Transduction*
  • Tumor Virus Infections / immunology*
  • Tumor Virus Infections / virology

Substances

  • Pathogen-Associated Molecular Pattern Molecules
  • Receptors, Pattern Recognition