Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov;2(11):1533-1542.
doi: 10.1038/s41564-017-0012-7. Epub 2017 Sep 11.

Recovery of Nearly 8,000 Metagenome-Assembled Genomes Substantially Expands the Tree of Life

Affiliations

Recovery of Nearly 8,000 Metagenome-Assembled Genomes Substantially Expands the Tree of Life

Donovan H Parks et al. Nat Microbiol. .

Erratum in

Abstract

Challenges in cultivating microorganisms have limited the phylogenetic diversity of currently available microbial genomes. This is being addressed by advances in sequencing throughput and computational techniques that allow for the cultivation-independent recovery of genomes from metagenomes. Here, we report the reconstruction of 7,903 bacterial and archaeal genomes from >1,500 public metagenomes. All genomes are estimated to be ≥50% complete and nearly half are ≥90% complete with ≤5% contamination. These genomes increase the phylogenetic diversity of bacterial and archaeal genome trees by >30% and provide the first representatives of 17 bacterial and three archaeal candidate phyla. We also recovered 245 genomes from the Patescibacteria superphylum (also known as the Candidate Phyla Radiation) and find that the relative diversity of this group varies substantially with different protein marker sets. The scale and quality of this data set demonstrate that recovering genomes from metagenomes provides an expedient path forward to exploring microbial dark matter.

Comment in

  • Finding life's missing pieces.
    Solden LM, Wrighton KC. Solden LM, et al. Nat Microbiol. 2017 Nov;2(11):1458-1459. doi: 10.1038/s41564-017-0048-8. Nat Microbiol. 2017. PMID: 29070823 No abstract available.

Similar articles

See all similar articles

Cited by 181 articles

See all "Cited by" articles

LinkOut - more resources

Feedback