Coupling progenitor and neuronal diversity in the developing neocortex

FEBS Lett. 2017 Dec;591(24):3960-3977. doi: 10.1002/1873-3468.12846. Epub 2017 Oct 16.

Abstract

The adult neocortex is composed of several types of glutamatergic neurons, which are sequentially born from progenitors during development. The extent and nature of progenitor diversity, and how it relates to neuronal diversity, is still poorly understood. In this review, we discuss key features of neocortical progenitors across several species, including their morphological properties, cell cycling behaviour and molecular signatures, and how these features relate to the competence of these cells to generate distinct types of progenies.

Keywords: neocortical development; neurogenesis; progenitor diversity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Cell Lineage / physiology*
  • Humans
  • Neocortex / embryology*
  • Neocortex / growth & development*
  • Neural Stem Cells / cytology*
  • Neural Stem Cells / physiology*
  • Neurogenesis / physiology
  • Neurons / physiology