Specific immunotypes of canine T cell lymphoma are associated with different outcomes

Vet Immunol Immunopathol. 2017 Sep:191:5-13. doi: 10.1016/j.vetimm.2017.07.008. Epub 2017 Jul 23.


Canine lymphoma is a heterogeneous disease with many different subtypes. Lymphoma of T cell type in particular is variable in outcome, and includes subtypes with non-progressive, slowly- and rapidly-progressive disease course. Association of immunotype with disease course is incompletely defined. Here, results of flow cytometric immunotyping of 127 canine T cell lymphomas were analyzed in relation to survival and progression free interval. Samples originated from 101 multicentric, 8 mediastinal, 6 cutaneous, 5 hepatosplenic, 5 gastrointestinal and 2 other anatomic subtypes of T cell lymphoma. Compared to multicentric T cell lymphoma, gastrointestinal lymphoma had shorter survival and progression free interval, and hepatosplenic lymphoma had shorter survival. Among dogs with multicentric T cell lymphoma, immunotypes of CD4+/CD8-/MHCII+, CD4-/CD8+/MHCII+ and CD4-/CD8+/MHCII- were associated with longer survival times than the immunotype of CD4+/CD8-/MHCII-, and immunotypes of CD4+/CD8-/MHCII+, CD4-/CD8+/MHCII-, and CD4-/CD8-/MHCII+ were associated with longer progression free intervals. Dogs with multicentric T cell lymphoma and concurrent leukemia had shorter survival but similar progression free interval compared to those without leukemia. Body weight, sex, hypercalcemia, cell size, expression of CD3 and use of combination or single agent chemotherapy did not significantly affect outcome of multicentric TCL.

Keywords: Cancer; Dog; Flow cytometry; Lymphosarcoma; Progression free interval; Survival.

MeSH terms

  • Animals
  • CD4-CD8 Ratio / veterinary
  • Dog Diseases / immunology*
  • Dog Diseases / mortality
  • Dog Diseases / pathology
  • Dogs
  • Female
  • Flow Cytometry / veterinary
  • Genes, MHC Class II / immunology
  • Lymph Nodes / pathology
  • Lymphoma, T-Cell / immunology
  • Lymphoma, T-Cell / mortality
  • Lymphoma, T-Cell / pathology
  • Lymphoma, T-Cell / veterinary*
  • Male
  • Prognosis