When LMO1 Meets MYCN, Neuroblastoma Is Metastatic

Cancer Cell. 2017 Sep 11;32(3):273-275. doi: 10.1016/j.ccell.2017.08.014.


LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metastatic disease progression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinogenesis / genetics
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neuroblastoma / genetics*
  • Nuclear Proteins / genetics
  • Oncogene Proteins / genetics
  • Zebrafish


  • Nuclear Proteins
  • Oncogene Proteins