Campylobacter pylori and recurrence of duodenal ulcers--a 12-month follow-up study

Lancet. 1987 Nov 14;2(8568):1109-11. doi: 10.1016/s0140-6736(87)91545-5.


In 39 patients with endoscopically healed duodenal ulcers repeat endoscopy and two antral biopsies after 1 year showed a relapse rate of 59%. Only post-treatment Campylobacter pylori status was a significant predictor of endoscopic relapse. 79% of patients who remained culture positive had a relapse, compared with 27% of culture-negative patients. Relapse was more likely (66%) in patients with a recurrence of C pylori after apparent eradication of the organism than in those who remained negative for C pylori (10%). No patient who remained negative for C pylori had histological gastritis, whereas all with recurrence of C pylori showed histological gastritis. These findings suggest an important role for C pylori in duodenal ulcer relapse in the year after treatment.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Campylobacter Infections / complications*
  • Campylobacter Infections / drug therapy
  • Campylobacter Infections / microbiology
  • Campylobacter Infections / pathology
  • Clinical Trials as Topic
  • Double-Blind Method
  • Duodenal Ulcer / drug therapy
  • Duodenal Ulcer / etiology*
  • Duodenal Ulcer / microbiology
  • Duodenal Ulcer / pathology
  • Endoscopy
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Organometallic Compounds / therapeutic use
  • Prospective Studies
  • Recurrence


  • Organometallic Compounds
  • bismuth tripotassium dicitrate