Clinical and Histological Evaluations of Enlarged Facial Skin Pores After Low Energy Level Treatments With Fractional Carbon Dioxide Laser in Korean Patients

Dermatol Surg. 2018 Mar;44(3):405-412. doi: 10.1097/DSS.0000000000001313.


Background: Enlarged facial pores can be an early manifestation of skin aging and they are a common aesthetic concern for Asians. However, studies of improving the appearance of enlarged pores have been limited.

Objective: The authors aimed to study the application of CO2 fractional laser treatment in patients with enlarged facial pores.

Methods: A total of 32 patients with dilated facial pores completed 3 consecutive sessions of low energy level treatments with a fractional CO2 laser at 4-week intervals. Image analysis was performed to calculate the number of enlarged pores before each treatment session and 12 weeks after the final treatment.

Results: After application of laser treatments, there was a significant decrease in the number of enlarged pores. The mean number of enlarged pores was decreased by 28.8% after the second session and by 54.5% at post-treatment evaluation. Post-treatment side effects were mild and transitory. Histological and immunohistochemical analyses demonstrated clear increases in the number of collagen fibers and the expression of transforming growth factor-β1.

Conclusion: The short-term results showed that treatment with low energy level CO2 fractional laser therapy could be a safe and effective option for patients with Fitzpatrick skin Types III and IV who are concerned with enlarged pores.

MeSH terms

  • Adult
  • Asian People
  • Face / pathology
  • Face / radiation effects*
  • Female
  • Humans
  • Lasers, Gas / therapeutic use*
  • Low-Level Light Therapy / instrumentation*
  • Male
  • Middle Aged
  • Prospective Studies
  • Skin / pathology*
  • Skin / radiation effects*
  • Skin Aging / pathology
  • Skin Aging / radiation effects*