Advanced glycation end-products (AGEs) accumulation in skin: relations with chronic kidney disease-mineral and bone disorder

J Bras Nefrol. Jul-Sep 2017;39(3):253-260. doi: 10.5935/0101-2800.20170042. Epub 2017 Aug 28.
[Article in En, Portuguese]

Abstract

Introduction: Chronic kidney disease (CKD) is associated with high morbidity and mortality rates, main causes related with cardiovascular disease (CVD) and bone mineral disorder (CKD-BMD). Uremic toxins, as advanced glycation end products (AGEs), are non-traditional cardiovascular risk factor and play a role on development of CKD-BMD in CKD. The measurement of skin autofluorescence (sAF) is a noninvasive method to assess the level of AGEs in tissue, validated in CKD patients.

Objective: The aim of this study is analyze AGEs measured by sAF levels (AGEs-sAF) and its relations with CVD and BMD parameters in HD patients.

Methods: Twenty prevalent HD patients (HD group) and healthy subjects (Control group, n = 24), performed biochemical tests and measurements of anthropometric parameters and AGEs-sAF. In addition, HD group performed measurement of intact parathormone (iPTH), transthoracic echocardiogram and radiographies of pelvis and hands for vascular calcification score.

Results: AGEs-sAF levels are elevated both in HD and control subjects ranged according to the age, although higher at HD than control group. Single high-flux HD session does not affect AGEs-sAF levels. AGEs-sAF levels were not related to ventricular mass, interventricular septum or vascular calcification in HD group. AGEs-sAF levels were negatively associated with serum iPTH levels.

Conclusion: Our study detected a negative correlation of AGEs-sAF with serum iPTH, suggesting a role of AGEs on the pathophysiology of bone disease in HD prevalent patients. The nature of this relation and the clinical application of this non-invasive methodology for evaluation AGEs deposition must be confirmed and clarified in future studies.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Chronic Kidney Disease-Mineral and Bone Disorder / diagnostic imaging
  • Chronic Kidney Disease-Mineral and Bone Disorder / metabolism*
  • Cross-Sectional Studies
  • Female
  • Glycation End Products, Advanced / analysis
  • Glycation End Products, Advanced / metabolism*
  • Humans
  • Male
  • Optical Imaging
  • Pilot Projects
  • Skin / diagnostic imaging
  • Skin / metabolism*

Substances

  • Glycation End Products, Advanced