Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study

Acta Cir Bras. 2017 Aug;32(8):626-632. doi: 10.1590/s0102-865020170080000004.

Abstract

Purpose:: To evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation.

Methods:: Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale.

Results:: The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale.

Conclusions:: Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Abdominal Wall / pathology
  • Abdominal Wall / surgery
  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Honey*
  • Hyaluronic Acid / therapeutic use*
  • Male
  • Metal Nanoparticles / therapeutic use*
  • Postoperative Complications / pathology
  • Postoperative Complications / prevention & control*
  • Random Allocation
  • Rats, Wistar
  • Reproducibility of Results
  • Sesame Oil / therapeutic use*
  • Severity of Illness Index
  • Silver / therapeutic use*
  • Time Factors
  • Tissue Adhesions / pathology
  • Tissue Adhesions / prevention & control*

Substances

  • Anti-Inflammatory Agents
  • Silver
  • Sesame Oil
  • Hyaluronic Acid