Linkage of DNA probe B79a (D7S13) to cystic fibrosis

Am J Hum Genet. 1987 Nov;41(5):944-7.


We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at theta = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cystic Fibrosis / genetics*
  • DNA / genetics*
  • Genetic Linkage*
  • Genetic Markers*
  • Humans
  • Polymorphism, Restriction Fragment Length


  • Genetic Markers
  • DNA