Extensive co-existence of neuropeptides in the rat visual cortex

Brain Res. 1987 Sep 8;420(1):95-9. doi: 10.1016/0006-8993(87)90243-5.

Abstract

The peroxidase-antiperoxidase immunohistochemical technique has been used to examine the co-existence of peptides within individual neurons of the rat visual cortex. Pairs of consecutive paraffin sections were stained alternately for 2 of the 4 peptides: somatostatin (SRIF), vasoactive intestinal polypeptide (VIP), cholecystokinin (CCK) and neuropeptide Y (NPY). Analysis revealed the co-existence of SRIF with VIP, CCK and NPY and between VIP and CCK. These results show that the co-localization of neuropeptides in cortical neurons is more widespread than previously demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholecystokinin / analysis
  • Cholecystokinin / physiology
  • Histocytochemistry
  • Immunoenzyme Techniques
  • Neuropeptide Y / analysis
  • Neuropeptide Y / physiology
  • Neuropeptides / analysis*
  • Neuropeptides / physiology
  • Rats
  • Rats, Inbred Strains
  • Somatostatin / analysis
  • Somatostatin / physiology
  • Vasoactive Intestinal Peptide / analysis
  • Vasoactive Intestinal Peptide / physiology
  • Visual Cortex / analysis*
  • Visual Cortex / cytology

Substances

  • Neuropeptide Y
  • Neuropeptides
  • Vasoactive Intestinal Peptide
  • Somatostatin
  • Cholecystokinin