ADHD is associated with migraine: a systematic review and meta-analysis

doi:10.1007/s00787-017-1045-4

Review

. 2018 Mar;27(3):267-277.

doi: 10.1007/s00787-017-1045-4. Epub 2017 Sep 13.

ADHD is associated with migraine: a systematic review and meta-analysis

Haitham Salem¹, David Vivas², Fei Cao¹, Iram F Kazimi², Antonio L Teixeira¹, Cristian P Zeni³

Affiliations

¹ Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
² Pediatric Mood Disorders/ADHD Across Lifespan Programs, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, 1941 East Road, Suite 3128, Houston, TX, 77054, USA.
³ Pediatric Mood Disorders/ADHD Across Lifespan Programs, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, 1941 East Road, Suite 3128, Houston, TX, 77054, USA. cpzeni@gmail.com.

PMID: 28905127
DOI: 10.1007/s00787-017-1045-4

Review

ADHD is associated with migraine: a systematic review and meta-analysis

Haitham Salem et al. Eur Child Adolesc Psychiatry. 2018 Mar.

. 2018 Mar;27(3):267-277.

doi: 10.1007/s00787-017-1045-4. Epub 2017 Sep 13.

Authors

Haitham Salem¹, David Vivas², Fei Cao¹, Iram F Kazimi², Antonio L Teixeira¹, Cristian P Zeni³

Affiliations

¹ Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
² Pediatric Mood Disorders/ADHD Across Lifespan Programs, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, 1941 East Road, Suite 3128, Houston, TX, 77054, USA.
³ Pediatric Mood Disorders/ADHD Across Lifespan Programs, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center, 1941 East Road, Suite 3128, Houston, TX, 77054, USA. cpzeni@gmail.com.

PMID: 28905127
DOI: 10.1007/s00787-017-1045-4

Abstract

An association between primary headaches and attention-deficit/hyperactivity disorder (ADHD) has long been suggested. Moreover, headache is regarded as a common side effect of stimulants, the most effective treatment for ADHD. So far, no systematic review has evaluated the potential association between ADHD and headache. We performed a systematic review of the literature and a meta-analysis of all reported studies on ADHD and primary headaches. Our analysis showed a positive association between ADHD and migraine (OR 1.322, 95% CI 1.018-1717, p value 0.036), but not with tension-type headache. There is a significant association between migraine and ADHD. The mechanisms underlying this association remain to be elucidated, warranting further studies.

Keywords: ADHD; Headache; Meta-analysis; Migraine; Stimulants; Tension-type headache.

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References

1. J Headache Pain. 2010 Feb;11(1):45-51 - PubMed
1. Seizure. 2013 Oct;22(8):647-50 - PubMed
1. J Child Adolesc Psychopharmacol. 2017 Oct;27(8):735-740 - PubMed
1. Cephalalgia. 2009 Jun;29(6):631-4 - PubMed
1. Curr Pain Headache Rep. 2015 Jul;19(7):25 - PubMed

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[1] J Headache Pain. 2010 Feb;11(1):45-51 - PubMed

[2] J Headache Pain. 2010 Feb;11(1):45-51 - PubMed

[3] Seizure. 2013 Oct;22(8):647-50 - PubMed

[4] Seizure. 2013 Oct;22(8):647-50 - PubMed

[5] J Child Adolesc Psychopharmacol. 2017 Oct;27(8):735-740 - PubMed

[6] J Child Adolesc Psychopharmacol. 2017 Oct;27(8):735-740 - PubMed

[7] Cephalalgia. 2009 Jun;29(6):631-4 - PubMed

[8] Cephalalgia. 2009 Jun;29(6):631-4 - PubMed

[9] Curr Pain Headache Rep. 2015 Jul;19(7):25 - PubMed

[10] Curr Pain Headache Rep. 2015 Jul;19(7):25 - PubMed

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ADHD is associated with migraine: a systematic review and meta-analysis

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ADHD is associated with migraine: a systematic review and meta-analysis

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