The 4D nucleome project

Nature. 2017 Sep 13;549(7671):219-226. doi: 10.1038/nature23884.


The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

MeSH terms

  • Animals
  • Cell Line
  • Cell Nucleus / genetics*
  • Cell Nucleus / physiology*
  • Chromatin / genetics
  • Chromatin / metabolism
  • Chromosomes / chemistry
  • Chromosomes / genetics
  • Chromosomes / metabolism
  • Genome*
  • Genomics / methods
  • Genomics / organization & administration
  • Goals
  • Humans
  • Information Dissemination
  • Mice
  • Models, Biological
  • Models, Molecular*
  • Molecular Imaging / methods*
  • Reproducibility of Results
  • Single-Cell Analysis
  • Spatio-Temporal Analysis*


  • Chromatin