Anti-VEGF treatment improves neurological function in tumors of the nervous system

Exp Neurol. 2018 Jan;299(Pt B):326-333. doi: 10.1016/j.expneurol.2017.09.008. Epub 2017 Sep 11.


Research of various diseases of the nervous system has shown that VEGF has direct neuroprotective effects in the central and peripheral nervous systems, and indirect effects on improving neuronal vessel perfusion which leads to nerve protection. In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function. This review aims to summarize the divergent roles of VEGF in diseases of the nervous system and the recent findings of anti-VEGF therapy in nerve damage/regeneration and function in tumors, specifically, in Neurofibromatosis type 2 associated schwannomas.

Keywords: Anti-VEGF treatment; Neurological function; Schwannoma.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cell Hypoxia / drug effects
  • Central Nervous System Neoplasms / blood supply
  • Central Nervous System Neoplasms / drug therapy*
  • Disease Models, Animal
  • Disease Progression
  • Humans
  • Molecular Targeted Therapy*
  • Neoplasm Proteins / antagonists & inhibitors*
  • Neoplasm Proteins / physiology
  • Neovascularization, Pathologic / drug therapy*
  • Neovascularization, Pathologic / etiology
  • Nerve Regeneration / drug effects
  • Nervous System Diseases / drug therapy
  • Nervous System Diseases / physiopathology
  • Neurofibromatosis 2*
  • Neuroma, Acoustic / blood supply
  • Neuroma, Acoustic / drug therapy*
  • Neuroma, Acoustic / genetics
  • Peripheral Nervous System Neoplasms / blood supply
  • Peripheral Nervous System Neoplasms / drug therapy*
  • Sciatic Nerve / blood supply
  • Sciatic Nerve / drug effects
  • Sciatic Nerve / physiopathology
  • Signal Transduction
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors*
  • Vascular Endothelial Growth Factor A / physiology


  • Antineoplastic Agents
  • Neoplasm Proteins
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A