Serotonin and norepinephrine reuptake inhibitors are second-line antidepressants largely used because of their good tolerance and their reduced side effects. Two of these drugs, duloxetine and venlafaxine, are used also in chronic pain management. In this review we present recent data regarding duloxetine's effects on the central nervous system, linked to acute pain management, and their efficiency in reducing postoperative chronic pain. The drug's efficacy results from its modulating effect on the descending inhibitory pain pathways and the inhibition of the nociceptive input. There are already several studies in favor of the analgesic properties of duloxetine. However, further and larger randomized studies are necessary in order to clarify duloxetine efficiency in acute postoperative settings, and thereafter on persistent chronic postoperative pain.
Keywords: acute postoperative pain; chronic post-surgical pain; duloxetine; serotonin-norepinephrine reuptake inhibitors.
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Cited by 3 PubMed Central articles
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Perioperative Duloxetine and Etoricoxibto Improve Postoperative Pain After Lumbar Laminectomy: A Randomized, Double-Blind, Controlled StudyJZ Attia et al. BMC Anesthesiol 17 (1), 162. PMID 29197345. - Randomized Controlled TrialThe perioperative administration of the combination of etoricoxib and duloxetine improved analgesia and reduced opioid consumption without significant side effects.