Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment

ACS Nano. 2017 Sep 26;11(9):9223-9230. doi: 10.1021/acsnano.7b04348. Epub 2017 Sep 15.


Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects. In order to enhance treatment efficiency with minimized side effects, we developed a transcutaneous browning agent patch to locally induce adipose tissue transformation. This microneedle-based patch can effectively deliver browning agents to the subcutaneous adipocytes in a sustained manner and switch on the "browning" at the targeted region. It is demonstrated that this patch reduces treated fat pad size, increases whole body energy expenditure, and improves type-2 diabetes in vivo in a diet-induced obesity mouse model.

Keywords: adipose tissue; browning agent; drug delivery; microneedle patch; obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adipocytes, White / drug effects
  • Adipose Tissue, White / drug effects*
  • Animals
  • Anti-Obesity Agents / administration & dosage*
  • Anti-Obesity Agents / therapeutic use
  • Drug Delivery Systems / instrumentation*
  • Hypoglycemic Agents / administration & dosage*
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Mice, Inbred C57BL
  • Obesity / drug therapy*
  • Rosiglitazone / administration & dosage*
  • Rosiglitazone / therapeutic use
  • Transdermal Patch*


  • Anti-Obesity Agents
  • Hypoglycemic Agents
  • Rosiglitazone