Behçet disease: New aspects

Clin Dermatol. 2017 Sep-Oct;35(5):421-434. doi: 10.1016/j.clindermatol.2017.06.004. Epub 2017 Jun 27.


Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. It is important to evaluate the patient with complex aphthosis for Behçet disease and related systemic disorders. We discuss the etiopathogenesis, clinical features, diagnostic criteria, and treatment approaches for complex aphthosis and Behçet disease in light of the current literature.

Publication types

  • Review

MeSH terms

  • Behcet Syndrome* / diagnosis
  • Behcet Syndrome* / etiology
  • Behcet Syndrome* / therapy
  • Humans
  • Recurrence
  • Stomatitis, Aphthous / etiology