Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy

Puja Van Epps; Robert C Kalayjian

doi:10.1016/j.idc.2017.07.007

Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy

Infect Dis Clin North Am. 2017 Dec;31(4):791-810. doi: 10.1016/j.idc.2017.07.007. Epub 2017 Sep 13.

Authors

Puja Van Epps¹, Robert C Kalayjian²

Affiliations

¹ Division of Infectious Diseases, Geriatric Research, Education, and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, 10701 East Boulevard, Cleveland, OH 44106, USA. Electronic address: puja.vanepps@va.gov.
² Division of Infectious Diseases, Geriatric Research, Education, and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, 10701 East Boulevard, Cleveland, OH 44106, USA; Division of Infectious Diseases, MetroHealth Medical Center, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.

PMID: 28916384
DOI: 10.1016/j.idc.2017.07.007

Abstract

Persons living with HIV (PLWH) have accentuated risks for age-associated comorbidities. Compared to the general population, PLWH have a 2-fold higher risk of cardiovascular disease, a 3-fold increased risk of fracture, and a risk of kidney disease that is comparable to that in diabetes. Some comorbidities may present at younger ages than among the general population, suggesting the possibility of accelerated aging with HIV infection.

Keywords: Aging; Comorbidities; Frailty; HIV; Senescence; Telomere.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged
Aging*
Anti-Retroviral Agents / therapeutic use*
HIV Infections / complications
HIV Infections / drug therapy*
Humans
Risk Factors

Substances

Anti-Retroviral Agents