Energy restriction combined with green coffee bean extract affects serum adipocytokines and the body composition in obese women

Asia Pac J Clin Nutr. 2017;26(6):1048-1054. doi: 10.6133/apjcn.022017.03.


Background and objectives: Obesity has become a public health problem and is a cause of some preventable illnesses. Among several methods for treating obesity, the use of food supplements is highly common. A commonly used food supplement is green coffee bean extract. The objective of this study was to evaluate the efficacy of green coffee bean extract combined with an energy-restricted diet on the body composition and serum adipocytokines in obese women.

Methods and study design: In this randomised clinical trial, 64 obese women aged 20-45 years were selected and divided into two groups: an intervention group (receiving 400 mg green coffee bean extract for 8 weeks) and control group (receiving placebo). All participants were on an energy-restricted diet. The body composition, leptin, adiponectin, lipid profile, free fatty acids (FFAs), and fasting blood sugar were compared between the two groups.

Results: We observed significant reductions in the body weight, body mass and fat mass indices, and waist-to-hip circumference ratio in both groups; however, the decrease was higher in the intervention group. Moreover, serum total cholesterol, low-density lipoprotein, leptin, and plasma free fatty acids significantly decreased in the intervention group (p<0.05) after adjustment for energy and fibre intake. The serum adiponectin concentration significantly increased in the intervention group (p<0.05).

Conclusions: Green coffee bean extract combined with an energy-restricted diet affects fat accumulation and lipid metabolism and is thus an inexpensive method for weight control in obese people.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adipokines / blood*
  • Adult
  • Body Composition / drug effects*
  • Coffea / chemistry*
  • Diet, Reducing
  • Dietary Supplements
  • Double-Blind Method
  • Energy Intake*
  • Female
  • Humans
  • Middle Aged
  • Obesity / diet therapy
  • Obesity / drug therapy*
  • Plant Extracts / pharmacology*
  • Young Adult


  • Adipokines
  • Plant Extracts