MR/K hemagglutination of Providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria

J Infect Dis. 1988 Feb;157(2):264-71. doi: 10.1093/infdis/157.2.264.


Providencia stuartii was the most prevalent bacterial species isolated, for one year, from weekly urine specimens from 51 long-term catheterized patients. Significantly more strains causing bacteriuric episodes of long duration expressed MR/K (mannose-resistant/Klebsiella-like) hemagglutination (74%) than did those causing episodes of short duration (26%; P = .004). Isolates expressing MR/K hemagglutinin bound in higher numbers to catheter material (P = .023) than did those not expressing this hemagglutinin. Significantly more strains causing bacteriuric episodes of short duration expressed the mannose-sensitive (MS) hemagglutinin (43%) than did those causing episodes of long duration (7%; P = .014). Isolates expressing MS hemagglutinin bound significantly more 125I-labeled Tamm-Horsfall protein (THP) than did isolates not expressing this hemagglutinin (P = .0001). Our results indicate that MR/K hemagglutinin plays an important role in the ability of P. stuartii to persist and suggest that MR/K adheres to the catheter. Conversely, MS hemagglutinin binds to THP and may prevent persistence of P. stuartii in the catheterized urinary tract.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bacterial Adhesion
  • Bacteriuria / epidemiology
  • Bacteriuria / microbiology*
  • Catheters, Indwelling
  • Female
  • Fimbriae, Bacterial
  • Hemagglutination*
  • Hemagglutinins / analysis
  • Humans
  • Male
  • Mannose
  • Mucoproteins / metabolism
  • Proteus / physiology*
  • Proteus Infections / epidemiology
  • Proteus Infections / microbiology*
  • Providencia / physiology*
  • Urinary Catheterization*
  • Uromodulin


  • Hemagglutinins
  • Mucoproteins
  • UMOD protein, human
  • Uromodulin
  • Mannose