A Redox Modulatory Mn 3 O 4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

Angew Chem Int Ed Engl. 2017 Nov 6;56(45):14267-14271. doi: 10.1002/anie.201708573. Epub 2017 Oct 4.


Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3 O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.

Keywords: biomimetic chemistry; enzyme catalysis; manganese; nanocatalysis; nanozymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / metabolism
  • Catalase / metabolism*
  • Cytoprotection*
  • Glutathione Peroxidase / metabolism*
  • Humans
  • Manganese Compounds / chemistry*
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Models, Biological
  • Nanostructures*
  • Oxidation-Reduction
  • Oxides / chemistry*
  • Parkinson Disease / enzymology
  • Parkinson Disease / metabolism*
  • Parkinson Disease / pathology
  • Reactive Oxygen Species / metabolism
  • Superoxide Dismutase / metabolism*
  • X-Ray Diffraction


  • Antioxidants
  • Manganese Compounds
  • Oxides
  • Reactive Oxygen Species
  • manganese oxide
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase