Somatostatin augments the M-current in hippocampal neurons

Science. 1988 Jan 15;239(4837):278-80. doi: 10.1126/science.2892268.

Abstract

Immunocytochemical and electrophysiological evidence suggests that somatostatin may be a transmitter in the hippocampus. To characterize the ionic mechanisms underlying somatostatin effects, voltage-clamp and current-clamp studies on single CA1 pyramidal neurons in the hippocampal slice preparation were performed. Both somatostatin-28 and somatostatin-14 elicited a steady outward current and selectively augmented the noninactivating, voltage-dependent outward potassium current known as the M-current. Since the muscarinic cholinergic agonists carbachol and muscarine antagonized this current, these results suggest a reciprocal regulation of the M-current by somatostatin and acetylcholine.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylcholine / pharmacology
  • Action Potentials / drug effects
  • Animals
  • Carbachol / pharmacology
  • Cesium / pharmacology
  • Electric Conductivity
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • Membrane Potentials
  • Muscarine / pharmacology
  • Neurons / drug effects
  • Neurons / physiology*
  • Potassium / metabolism*
  • Rats
  • Somatostatin / pharmacology*
  • Somatostatin-28

Substances

  • Cesium
  • Somatostatin
  • Somatostatin-28
  • Muscarine
  • Carbachol
  • Acetylcholine
  • Potassium