Baicalein as a potent neuroprotective agent: A review

Biomed Pharmacother. 2017 Nov;95:1021-1032. doi: 10.1016/j.biopha.2017.08.135. Epub 2017 Sep 13.


In recent times, neurodegenerative diseases are the most challenging global health problems. Neuronal cell death or damage is a key factor for many neurodegenerative disorders. Therefore, there has been a growing interest in the development of effective neuroprotective agents, especially from natural sources. In particular, phytochemicals have shown high efficacy with low side effects in various in vitro and in vivo studies. In the various phytoconstituents, flavonoids are important bioactive products and mainly found in various vegetables and fruits. Among them, baicalein is one of the important flavones, which is mainly found in the root of Scutellaria baicalensis Georgi. A number of studies have reported that baicalein has potent neuroprotective properties under in vitro as well as in vivo systems. Hence, the purpose of this paper is to provide a review of the existing literature in connection with the neuroprotective effects of baicalein and its molecular mechanisms of action. The current review highlights could be useful to identify novel therapeutic agents in relation to the treatment of neurotoxicity-mediated diseases.

Keywords: Alzheimer’s disease; Baicalein; Neuroprotective; Parkinson’s disease; Scutellaria baicalensis.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Availability
  • Blood-Brain Barrier / drug effects
  • Blood-Brain Barrier / pathology
  • Disease Models, Animal
  • Flavanones / chemistry
  • Flavanones / pharmacology*
  • Humans
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology*


  • Flavanones
  • Neuroprotective Agents
  • baicalein