A genome-wide association study of early gamma-band response in a schizophrenia case-control sample

World J Biol Psychiatry. 2018 Dec;19(8):602-609. doi: 10.1080/15622975.2017.1366054. Epub 2017 Sep 19.


Objectives: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity.

Methods: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315).

Results: No marker surpassed the threshold for genome-wide significant association. Several of the markers that were closest to significance mapped to genes involved in neuronal development and the Neuregulin-ErbB signalling network, such as NRG2 and KALRN. Using a gene-set enrichment analysis, we found suggestive evidence for association with genes involved in EEG abnormality (P = .048).

Conclusions: We identified no marker genome-wide significantly associating with gamma response; independent replication of the gene-set analysis result and larger sample sizes will be required to provide leads to cellular pathways involved in gamma-band activity.

Keywords: EEG; GWAS; Neuregulin-ErbB; gamma; schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Electroencephalography
  • Evoked Potentials, Auditory / physiology*
  • Female
  • Gamma Rhythm / physiology*
  • Genome-Wide Association Study*
  • Humans
  • Male
  • Middle Aged
  • Schizophrenia / genetics*
  • Schizophrenia / physiopathology*