Genetic and epigenetic studies of adiposity and cardiometabolic disease

Michael V Holmes; Sara L Pulit; Cecilia M Lindgren

doi:10.1186/s13073-017-0474-5

Genetic and epigenetic studies of adiposity and cardiometabolic disease

Genome Med. 2017 Sep 18;9(1):82. doi: 10.1186/s13073-017-0474-5.

Authors

Michael V Holmes^{1

2

3

4}, Sara L Pulit^{5

6

7}, Cecilia M Lindgren^{8

9

10

11}

Affiliations

¹ Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK. michael.holmes@ndph.ox.ac.uk.
² Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK. michael.holmes@ndph.ox.ac.uk.
³ Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. michael.holmes@ndph.ox.ac.uk.
⁴ National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK. michael.holmes@ndph.ox.ac.uk.
⁵ The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
⁶ Medical Population and Genetics Program, Broad Institute, Cambridge, MA, USA.
⁷ Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
⁸ National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK. celi@well.ox.ac.uk.
⁹ The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. celi@well.ox.ac.uk.
¹⁰ Medical Population and Genetics Program, Broad Institute, Cambridge, MA, USA. celi@well.ox.ac.uk.
¹¹ Wellcome Trust Center for Human Genetics, Oxford University, Oxford, UK. celi@well.ox.ac.uk.

Abstract

Over 300 million adults are obese, but little is known about the impact of obesity on cardiovascular health. We discuss recent genetic and epigenetic studies of adiposity that indicate a causal role for general and central adiposity in cardiometabolic disease, and highlight potential mechanisms including insulin resistance and gene expression.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Adiposity / genetics*
Cardiovascular Diseases / genetics*
Cardiovascular Diseases / metabolism
Epigenomics
Humans
Insulin Resistance / genetics*

Abstract

Publication types

MeSH terms

Grant support