Genetic and epigenetic studies of adiposity and cardiometabolic disease

Genome Med. 2017 Sep 18;9(1):82. doi: 10.1186/s13073-017-0474-5.


Over 300 million adults are obese, but little is known about the impact of obesity on cardiovascular health. We discuss recent genetic and epigenetic studies of adiposity that indicate a causal role for general and central adiposity in cardiometabolic disease, and highlight potential mechanisms including insulin resistance and gene expression.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adiposity / genetics*
  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / metabolism
  • Epigenomics
  • Humans
  • Insulin Resistance / genetics*