Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 9 (7), e1438

Anti-inflammatory and Antioxidant Effects of Sesame Oil on Atherosclerosis: A Descriptive Literature Review


Anti-inflammatory and Antioxidant Effects of Sesame Oil on Atherosclerosis: A Descriptive Literature Review

Edmund Hsu et al. Cureus.


Sesame oil (SO) is a supplement that has been known to have anti-inflammatory and antioxidant properties, which makes it effective for reducing atherosclerosis and the risk of cardiovascular disease. Due to the side effects of statins, the current recommended treatment for atherosclerosis and cardiovascular diseases, the idea of using dietary and nutritional supplementation has been explored. The benefits of a dietary health regime have piqued curiosity because many different cultures have reaped health benefits through the ingredients in their cooking with negligible side effects. The purpose of this literary review is to provide a broad overview of the potential benefits and risks of SO on the development of atherosclerosis and its direction toward human clinical use. Current in vivo and in vitro research has shed light on the effects of SO and its research has shown that SO can decrease low-density lipoprotein (LDL) levels while maintaining high-density lipoprotein (HDL) levels. Current limitations in recent studies include no standardized doses of SO given to subjects and unknown specific mechanisms of the different components of SO. Future studies should explore possible synergistic and adverse effects of SO when combined with current recommended pharmaceutical therapies and other adjunct treatments.

Keywords: anti-inflammatory; antioxidant; atherosclerosis; cardiovascular disease; sesame oil.

Conflict of interest statement

The authors have declared that no competing interests exist.

Similar articles

See all similar articles

Cited by 3 PubMed Central articles


    1. Heart disease and stroke statistics—2016 update: a report from the American heart association. Mozaffarian D, Benjamin EJ, Go AS, et al. Circulation. 2015;133:16.
    1. The pathogenesis of atherosclerosis: a perspective for the 1990s. Ross R. Nature. 1993;362:801–809. - PubMed
    1. Role of oxidative stress in cardiovascular diseases. Dhalla NS, Temsah RM, Netticadan T. J Hypertens. 2000;18:655–673. - PubMed
    1. The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Parthasarathy S, Steinberg D, Witztum JL. Annu Rev Med. 1992;43:219–225. - PubMed
    1. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Tedgui A, Mallat Z. Physiol Rev. 2006;86:515–581. - PubMed

LinkOut - more resources