Incidence of perforated and bleeding peptic ulcers before and after the introduction of H2-receptor antagonists

Ann Surg. 1988 Jan;207(1):4-6. doi: 10.1097/00000658-198801000-00002.

Abstract

The incidence of perforated and bleeding peptic ulcer requiring emergency surgery was studied in a defined population before and after the introduction of histamine H2-blockers. The incidence of these ulcer complications was unchanged from 1974 to 1984 with an incidence of ulcer perforation from 4 to 10/100,000 per year and of bleeding ulcer from 5 to 10/100,000, indicating that the H2-blockers have not changed the incidence of severe ulcer complications.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Duodenal Ulcer / complications*
  • Duodenal Ulcer / drug therapy
  • Female
  • Histamine H2 Antagonists / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Peptic Ulcer Hemorrhage / epidemiology*
  • Peptic Ulcer Hemorrhage / surgery
  • Peptic Ulcer Perforation / epidemiology*
  • Peptic Ulcer Perforation / surgery
  • Stomach Ulcer / complications*
  • Stomach Ulcer / drug therapy

Substances

  • Histamine H2 Antagonists