Lipofuscin deposition causes the pigmentation of apocrine hidrocystoma

J Dermatol. 2018 Jan;45(1):91-94. doi: 10.1111/1346-8138.14037. Epub 2017 Sep 18.


Apocrine hidrocystoma (AHC) is a benign cystic lesion arising from apocrine glands and frequently presents as a blue hae with a whitish gloss. It has been reported that the amount of lipofuscin and the degree of its oxidation determines the pigmentation of AHC. However, little is known about the correlation between clinical color and lipofuscin granules. In this study, we histopathologically investigated three cases of AHC and statistically analyzed the quantitative correlation between the clinical color tone and the amount of cytoplasmic lipofuscin deposits. The color tone was quantified as the mean gray value using Image J software. Statistical analysis showed a negative correlative tendency (P = 0.09) between the color tone and the amount of lipofuscin. Our study suggests that the color tone of AHC is associated with the amount of lipofuscin.

Keywords: Schmorl's staining; apocrine hidrocystoma; lipofuscin; melanin; pigmentation.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Female
  • Hidrocystoma / metabolism
  • Hidrocystoma / pathology*
  • Humans
  • Lipofuscin / metabolism*
  • Male
  • Pigmentation*
  • Sweat Gland Neoplasms / metabolism
  • Sweat Gland Neoplasms / pathology*
  • Sweat Glands / metabolism
  • Sweat Glands / pathology*


  • Lipofuscin