Laminin associated with BMP7 as potential secondary astrocytic glioma fiber differentiation targets

Eur Rev Med Pharmacol Sci. 2017 Aug;21(16):3611-3616.


Objective: To investigate the activation of the BMP7 and laminin pathway is associated with glioma cell proliferation and differentiation.

Patients and methods: We enrolled 65 patients with primary operable glioma. Laminin and BMP7 protein expression and its subcellular localization were studied by immunofluorescence.

Results: We detected a higher level of BMP7 expression in glioma tissue in patients with a lower grade of glioma who had a lower eosinophil count. Compared to patients with a higher grade of glioma, we observed a lower level of laminin expression in patients with a lower grade of glioma.

Conclusions: Our data indicated a potential link between eosinophil counts and the expression levels of laminin and BMP7 in glioma differentiation.

MeSH terms

  • Adult
  • Astrocytoma / blood
  • Astrocytoma / chemistry
  • Astrocytoma / pathology*
  • Bone Morphogenetic Protein 7 / analysis*
  • Brain Neoplasms / blood
  • Brain Neoplasms / chemistry
  • Brain Neoplasms / pathology*
  • Cell Differentiation
  • Eosinophils
  • Female
  • Humans
  • Laminin / analysis*
  • Male
  • Middle Aged


  • BMP7 protein, human
  • Bone Morphogenetic Protein 7
  • Laminin