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. 2017 Oct 2;216(10):2995-2997.
doi: 10.1083/jcb.201709034. Epub 2017 Sep 19.

A new Rab7 effector controls phosphoinositide conversion in endosome maturation

James E Casanova  1 , Bettina Winckler  2
Affiliations

A new Rab7 effector controls phosphoinositide conversion in endosome maturation

James E Casanova et al. J Cell Biol. .

Abstract

Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome maturation, viability, and dendrite growth of neurons in vivo.

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Figures

Figure 1.
Figure 1.
The complexes that form during endosome maturation as Rabs and phosphoinositides are converted are shown. WDR91 binds both Rab7 and Beclin1 and can inhibit the activity of Vps34, thus reducing the levels of PtdIns3P on the endosomal membrane, which is necessary for endosome maturation.
See this image and copyright information in PMC

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