Protective effect of the glutamate antagonist, MK-801 in focal cerebral ischemia in the cat

J Cereb Blood Flow Metab. 1988 Feb;8(1):138-43. doi: 10.1038/jcbfm.1988.18.


The effects of the glutamate N-methyl-D aspartate (NMDA) receptor antagonist, MK-801, upon ischemic brain damage has been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery and the animal were killed 6 h later. The amount of early ischemic damage was assessed in coronal sections at 16 predetermined stereotactic planes. Pretreatment with MK-801 (5 mg/kg, i.v.), 30 min before occlusion of the middle cerebral artery significantly reduced the volume of ischemic damage (from 32.7 +/- 4.0% of the cerebral hemisphere in vehicle-treated cats to 16.2 +/- 4.5% in MK-801-treated cats). NMDA receptor antagonists that penetrate the blood-brain barrier, such as MK-801, merit further study as protective agents against ischemic brain damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Brain / drug effects
  • Brain / pathology*
  • Cats
  • Cell Nucleus / pathology
  • Cerebral Cortex / pathology
  • Cytoplasm / pathology
  • Dibenzocycloheptenes / pharmacology
  • Dibenzocycloheptenes / therapeutic use*
  • Dizocilpine Maleate
  • Excitatory Amino Acid Antagonists*
  • Female
  • Glutamic Acid
  • Ischemic Attack, Transient / drug therapy
  • Ischemic Attack, Transient / pathology*
  • Male
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects


  • Dibenzocycloheptenes
  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • Glutamic Acid
  • Dizocilpine Maleate