Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 29 (3), 344-357

Stress Ulcer Prophylaxis in Neurocritical Care


Stress Ulcer Prophylaxis in Neurocritical Care

Jeffrey F Barletta et al. Neurocrit Care.


Stress ulcer prophylaxis (SUP) with acid-suppressive drug therapy is widely utilized in critically ill patients following neurologic injury for the prevention of clinically important stress-related gastrointestinal bleeding (CIB). Data supporting SUP, however, largely originates from studies conducted during an era where practices were vastly different than what is considered routine by today's standard. This is particularly true in neurocritical care patients. In fact, the routine provision of SUP has been challenged due to an increasing prevalence of adverse drug events with acid-suppressive therapy and the perception that CIB rates are sparse. This narrative review will discuss current controversies with SUP as they apply to neurocritical care patients. Specifically, the pathophysiology, prevalence, and risk factors for CIB along with the comparative efficacy, safety, and cost-effectiveness of acid-suppressive therapy will be described.

Keywords: Acid-suppressive therapy; Adverse drug events; Gastrointestinal hemorrhage; Histamine-2-receptor antagonists; Neurocritical care; Proton pump inhibitors; Stress ulcer prophylaxis.

Similar articles

See all similar articles


    1. Value Health. 2013 Jan-Feb;16(1):14-22 - PubMed
    1. Crit Care Med. 1993 Dec;21(12):1844-9 - PubMed
    1. Acta Neurochir Suppl. 2011;111:435-9 - PubMed
    1. J Crit Care. 2014 Aug;29(4):696.e11-5 - PubMed
    1. Neurosurgery. 1989 Sep;25(3):378-82 - PubMed

MeSH terms


LinkOut - more resources