Foundations of Immunometabolism and Implications for Metabolic Health and Disease

Immunity. 2017 Sep 19;47(3):406-420. doi: 10.1016/j.immuni.2017.08.009.


Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Biological Evolution
  • Cell Communication / immunology
  • Cytokines / metabolism
  • Energy Metabolism*
  • Glucose / metabolism
  • Humans
  • Immune System / cytology
  • Immune System / immunology
  • Immune System / metabolism
  • Immunity*
  • Immunity, Innate
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation Mediators
  • Metabolic Diseases / immunology*
  • Metabolic Diseases / metabolism*
  • Metabolic Diseases / therapy
  • Organ Specificity
  • Signal Transduction
  • Translational Research, Biomedical


  • Cytokines
  • Inflammation Mediators
  • Glucose