Genomic imprinting and carcinogenesis

Lancet. 1988 Feb 13;1(8581):329-31. doi: 10.1016/s0140-6736(88)91121-x.


Genomic imprinting might play an important part in the development of several tumours. It is suggested that in Wilms' tumorigenesis, imprinting normally renders inactive a transforming gene on the maternally derived chromosome 11, leaving intact the paternally inherited chromosome 11 and the Wilms' transforming gene that it carries. A similar mechanism might account for the inheritance patterns of other tumours.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles*
  • Chromosome Aberrations / genetics*
  • Chromosome Deletion*
  • Chromosome Disorders
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Female
  • Humans
  • Male
  • Models, Biological
  • Suppression, Genetic*
  • Wilms Tumor / genetics*