A double-blind, randomised, placebo-controlled trial of fish oil in psoriasis

Lancet. 1988 Feb 20;1(8582):378-80. doi: 10.1016/s0140-6736(88)91181-6.


28 patients with stable chronic psoriasis completed a trial in which they were randomly allocated to receive either 10 fish-oil capsules ('MaxEPA') or 10 placebo capsules (olive oil) daily. Patients were specifically instructed not to change their normal diet. After 8 weeks' treatment there was a significant lessening of itching, erythema, and scaling in the active treatment group, with a trend towards an overall decrease in body surface area affected. No change occurred in the placebo group.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Docosahexaenoic Acids*
  • Double-Blind Method
  • Drug Combinations
  • Drug Evaluation
  • Eicosapentaenoic Acid*
  • Fatty Acids, Unsaturated / therapeutic use*
  • Female
  • Fish Oils / therapeutic use*
  • Humans
  • Male
  • Psoriasis / drug therapy*
  • Random Allocation


  • Drug Combinations
  • Fatty Acids, Unsaturated
  • Fish Oils
  • Maxepa
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid