Langerhans cell histiocytosis limited to the female genital tract: A review of literature with three additional cases

Rebekah Wieland; Jenna Flanagan; Elise Everett; Sharon Mount

doi:10.1016/j.gore.2017.08.005

Langerhans cell histiocytosis limited to the female genital tract: A review of literature with three additional cases

Gynecol Oncol Rep. 2017 Aug 26:22:4-8. doi: 10.1016/j.gore.2017.08.005. eCollection 2017 Nov.

Authors

Rebekah Wieland^{1

2}, Jenna Flanagan³, Elise Everett³, Sharon Mount²

Affiliations

¹ College of Medicine, University of Vermont, Burlington, VT, USA.
² Department of Pathology and Laboratory Medicine, The University of Vermont Medical Center, Burlington, VT, USA.
³ Gynecological Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Vermont Medical Center, Burlington, VT, USA.

Abstract

•LCH of the female reproductive tract has four patterns of involvement.•A comprehensive literature review revealed 35 cases of pure genital LCH.•We report two new cases of pure LCH lesions of the vulva and one of the cervix.•Treatment of LCH varies and there is no standard for pure genital involvement.•Prognosis of LCH confined to the gynecologic tract appears to be favorable.

Keywords: Cervix; Dendritic neoplasm; Histiocytic neoplasm; Langerhans cell histiocytosis; Vulva.

Publication types

Case Reports