Thermoresponsive cyclodextrins with benzenesulfonamide showing tunable inhibition for carbonic anhydrase

Apan Qian; Huang Shi; Runlang Zhu; Jiatao Yan; Wen Li; Kun Liu; Afang Zhang

doi:10.1039/c7ob02171b

Thermoresponsive cyclodextrins with benzenesulfonamide showing tunable inhibition for carbonic anhydrase

Org Biomol Chem. 2017 Oct 4;15(38):8028-8031. doi: 10.1039/c7ob02171b.

Authors

Apan Qian¹, Huang Shi, Runlang Zhu, Jiatao Yan, Wen Li, Kun Liu, Afang Zhang

Affiliation

¹ Laboratory of Polymer Chemistry, Department of Polymer Materials, College of Materials Science and Engineering, Shanghai University, Materials Building Room 447, Nanchen Street 333, Shanghai 200444, China. jiataoyan@shu.edu.cn azhang@shu.edu.cn.

PMID: 28933488
DOI: 10.1039/c7ob02171b

Abstract

Monodisperse thermoresponsive cyclodextrins appended with benzenesulfonamides were demonstrated to reversibly regulate the enzymatic activity of carbonic anhydrase, which was found to be dependent on both scaffold effect and thermoresponsiveness.

MeSH terms

Benzenesulfonamides
Carbonic Anhydrase Inhibitors / pharmacology*
Carbonic Anhydrases / chemistry
Carbonic Anhydrases / metabolism*
Cyclodextrins / chemistry
Cyclodextrins / pharmacology*
Molecular Structure
Sulfonamides / chemistry
Sulfonamides / pharmacology*

Substances

Carbonic Anhydrase Inhibitors
Cyclodextrins
Sulfonamides
Carbonic Anhydrases