d-Allulose enhances postprandial fat oxidation in healthy humans

Nutrition. Nov-Dec 2017;43-44:16-20. doi: 10.1016/j.nut.2017.06.007. Epub 2017 Jul 6.


Objective: d-Allulose, a C-3 epimer of d-fructose, has been reported to decrease body weight and adipose tissue weight in animal studies and is expected to be a potent antiobese sweetener. Our animal study suggested that one of the mechanisms of d-allulose's antiobesity function is an increase in energy expenditure. However, a few studies have thus far explored the underlying mechanism in humans. The aim of this study was to examine the effects of a single ingestion of d-allulose on postprandial energy metabolism in healthy participants.

Methods: Thirteen healthy men and women (mean age of 35.7 ± 2.1 y and body mass index 20.9 ± 0.7 kg/m2) were studied. The study was a randomized, single-blind crossover design with a 1-wk washout period. At 30 min after taking 5 g of d-allulose or 10 mg of aspartame without any sugar as a control, overnight-fasted participants ingested a standardized meal, and energy metabolism was evaluated by a breath-by-breath method. During the experiment, blood was collected and biochemical parameters such as plasma glucose were analyzed.

Results: In the d-allulose-treated group, the area under the curve of fat oxidation was significantly higher than in the control group (10.5 ± 0.4 versus 9.6 ± 0.3 kJ·4 h·kg-1 body weight [BW]; P < 0.05), whereas that of carbohydrate oxidation was significantly lower (8.1 ± 0.5 versus 9.2 ± 0.5 kJ·4 h·kg-1 BW; P < 0.05). Furthermore, plasma glucose levels were significantly lower, and free fatty acid levels were significantly higher in the d-allulose group than in the control group. No other parameters such as insulin, total cholesterol, or triacylglycerol were modified.

Conclusion: d-Allulose enhances postprandial fat oxidation in healthy humans, indicating that it could be a novel sweetener to control and maintain healthy body weight, probably through enhanced energy metabolism.

Keywords: Energy expenditure; Fat oxidation; Obesity; Rare sugar; d-allulose; d-psicose.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adipose Tissue / metabolism
  • Adult
  • Aspartame / administration & dosage
  • Blood Glucose / analysis
  • Body Mass Index
  • Body Weight / drug effects
  • Cross-Over Studies
  • Dietary Carbohydrates / metabolism
  • Dietary Fats / metabolism*
  • Energy Metabolism / drug effects
  • Fatty Acids, Nonesterified / blood
  • Female
  • Fructose / administration & dosage*
  • Humans
  • Insulin / blood
  • Male
  • Oxidation-Reduction
  • Postprandial Period*
  • Single-Blind Method
  • Sweetening Agents


  • Blood Glucose
  • Dietary Carbohydrates
  • Dietary Fats
  • Fatty Acids, Nonesterified
  • Insulin
  • Sweetening Agents
  • psicose
  • Fructose
  • Aspartame