Mitochondrial adaptation in steatotic mice

Mitochondrion. 2018 May:40:1-12. doi: 10.1016/j.mito.2017.08.015. Epub 2017 Sep 19.


Western lifestyle-associated malnutrition causes steatosis that may progress to liver inflammation and mitochondrial dysfunction has been suggested as a key factor in promoting this disease. Here we have molecularly, biochemically and biophysically analyzed mitochondria from steatotic wild type and immune-compromised mice fed a Western diet (WD) - enriched in saturated fatty acids (SFAs). WD-mitochondria demonstrated lipidomic changes, a decreased mitochondrial ATP production capacity and a significant sensitivity to calcium. These changes preceded hepatocyte damage and were not associated with enhanced ROS production. Thus, WD-mitochondria do not promote steatohepatitis per se, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.

Keywords: Mitochondria; NAFLD; Steatosis; Western diet.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Adenosine Triphosphate / metabolism
  • Animals
  • Calcium / metabolism
  • Diet / methods
  • Disease Models, Animal
  • Fatty Acids / administration & dosage
  • Fatty Liver / pathology*
  • Hepatocytes / pathology*
  • Lipid Metabolism
  • Mice
  • Mitochondria / metabolism
  • Mitochondria / physiology*


  • Fatty Acids
  • Adenosine Triphosphate
  • Calcium