Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 2;8(35):59929-59939.
doi: 10.18632/oncotarget.18349. eCollection 2017 Aug 29.

Preclinical Evidence of Ghrelin as a Therapeutic Target in Epilepsy

Free PMC article

Preclinical Evidence of Ghrelin as a Therapeutic Target in Epilepsy

Tongtong Ge et al. Oncotarget. .
Free PMC article


Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin's anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy.

Keywords: epilepsy; ghrelin; hippocampus; memory; neuroprotection.

Conflict of interest statement

CONFLICTS OF INTEREST The authors confirm that this article content has no conflicts of interest.

Similar articles

See all similar articles

Cited by 5 articles


    1. Manjarrez-Marmolejo J, Franco-Pérez J. Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models. Curr Neuropharmacol. 2016;14:759–71. - PMC - PubMed
    1. Ribierre T, Baulac S. mTOR pathway in familial focal epilepsies. Oncotarget. 2017;8:5674–5675. - DOI - PMC - PubMed
    1. Liu W, Ge T, Pan Z, Leng Y, Lv J, Li B. The effects of herbal medicine on epilepsy. Oncotarget. 2017;8:48385–48397. - DOI - PMC - PubMed
    1. Beck H, Elger CE. Epilepsy research: a window onto function to and dysfunction of the human brain. Dialogues Clin Neurosci. 2008;10:7–15. - PMC - PubMed
    1. Robens B, Becker AJ. Molecular rescue of Tsc1-ablated cortical tuber mice. Oncotarget. 2017;8:5678–5679. - DOI - PMC - PubMed

LinkOut - more resources