A new CTGF target in renal fibrosis

John R Montford; Seth B Furgeson

doi:10.1016/j.kint.2017.04.042

A new CTGF target in renal fibrosis

Kidney Int. 2017 Oct;92(4):784-786. doi: 10.1016/j.kint.2017.04.042.

Authors

John R Montford¹, Seth B Furgeson²

Affiliations

¹ Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Renal Section, Denver Veterans Affairs Medical Center, Denver, Colorado, USA.
² Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Department of Medicine, Denver Health Hospital, Denver, Colorado, USA; Consortium for Fibrosis Research and Translation, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: seth.furgeson@ucdenver.edu.

PMID: 28938948
DOI: 10.1016/j.kint.2017.04.042

Abstract

Lymphangiogenesis appears to accompany renal fibrosis, but signals that regulate the lymphangiogenic growth factor vascular endothelial growth factor C are not well understood. Kinashi et al. have shown that conditionally deleting connective tissue growth factor reduces renal fibrosis, vascular endothelial growth factor C, and lymphangiogenesis. Connective tissue growth factor has pleiotropic effects in the setting of renal fibrosis; this study adds a potentially new mechanism for the profibrotic effects of connective tissue growth factor.

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MeSH terms

Connective Tissue Growth Factor*
Fibrosis
Humans
Intercellular Signaling Peptides and Proteins
Kidney Diseases
Lymphangiogenesis
Vascular Endothelial Growth Factor C*

Substances

CCN2 protein, human
Intercellular Signaling Peptides and Proteins
Vascular Endothelial Growth Factor C
Connective Tissue Growth Factor