Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts

Exp Dermatol. 2018 Oct;27(10):1170-1172. doi: 10.1111/exd.13451. Epub 2017 Nov 10.


This study was undertaken to evaluate whether exosomes from human adipose-derived stem cells (ASC-exo) can stimulate the regeneration of human dermal fibroblasts (HDFs). Immunoblotting and FACS analyses showed that ASC-exo was positive for exosome markers. Fluorescence tracking revealed that the contents of ASC-exo were transferred into the HDFs. ASC-exo treatment also stimulated the proliferation and migration of HDFs in a dose-dependent manner. Similarly, the expression levels of genes involved in skin cell proliferation were increased by ASC-exo. Microarray analysis showed an enrichment of microRNAs that have regenerative function. We suggest that the ASC-exo can stimulate skin cell proliferation.

Keywords: extracellular vesicle; microRNA array; skin regeneration; wound healing.

Publication types

  • Letter

MeSH terms

  • Adipose Tissue / cytology
  • Cell Movement*
  • Cell Proliferation*
  • Cells, Cultured
  • Exosomes*
  • Fibroblasts / physiology*
  • Humans
  • MicroRNAs / analysis*
  • Oligonucleotide Array Sequence Analysis
  • Regeneration
  • Skin / cytology
  • Stem Cells


  • MicroRNAs