Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct;27(10):1170-1172.
doi: 10.1111/exd.13451. Epub 2017 Nov 10.

Exosomes From Human Adipose-Derived Stem Cells Promote Proliferation and Migration of Skin Fibroblasts

Affiliations

Exosomes From Human Adipose-Derived Stem Cells Promote Proliferation and Migration of Skin Fibroblasts

Eun Wook Choi et al. Exp Dermatol. .

Abstract

This study was undertaken to evaluate whether exosomes from human adipose-derived stem cells (ASC-exo) can stimulate the regeneration of human dermal fibroblasts (HDFs). Immunoblotting and FACS analyses showed that ASC-exo was positive for exosome markers. Fluorescence tracking revealed that the contents of ASC-exo were transferred into the HDFs. ASC-exo treatment also stimulated the proliferation and migration of HDFs in a dose-dependent manner. Similarly, the expression levels of genes involved in skin cell proliferation were increased by ASC-exo. Microarray analysis showed an enrichment of microRNAs that have regenerative function. We suggest that the ASC-exo can stimulate skin cell proliferation.

Keywords: extracellular vesicle; microRNA array; skin regeneration; wound healing.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles

LinkOut - more resources

Feedback