A Novel Tool for Predicting Extracapsular Extension During Graded Partial Nerve Sparing in Radical Prostatectomy

BJU Int. 2018 Mar;121(3):373-382. doi: 10.1111/bju.14026. Epub 2017 Oct 22.

Abstract

Objectives: To create a statistical tool for the estimation of extracapsular extension (ECE) level of prostate cancer and determine the nerve-sparing (NS) approach that can be safely performed during radical prostatectomy (RP).

Patients and methods: A total of 11 794 lobes, from 6 360 patients who underwent robot-assisted RP between 2008 and 2016 were evaluated. Clinicopathological features were included in a statistical algorithm for the prediction of the maximum ECE width. Five multivariable logistic models were estimated for: presence of ECE and ECE width of >1, >2, >3, and >4 mm. A five-zone decision rule based on a lower and upper threshold is proposed. Using a graphical interface, surgeons can view patient's pre-treatment characteristics and a curve showing the estimated probabilities for ECE amount together with the areas identified by the decision rule.

Results: Of the 6 360 patients, 1 803 (28.4%) were affected by non-organ-confined disease. ECE was present in 1 351 lobes (11.4%) and extended beyond the capsule for >1, >2, >3, and >4 mm in 498 (4.2%), 261 (2.2%), 148 (1.3%), 99 (0.8%) cases, respectively. ECE width was up to 15 mm (interquartile range 1.00-2.00). The five logistic models showed good predictive performance, the area under the receiver operating characteristic curve was: 0.81 for ECE, and 0.84, 0.85, 0.88, and 0.90 for ECE width of >1, >2, >3, and >4 mm, respectively.

Conclusion: This novel tool predicts with good accuracy the presence and amount of ECE. Furthermore, the graphical interface available at www.prece.it can support surgeons in patient counselling and preoperative planning.

Keywords: extracapsular extension; nomogram; prostate; prostate cancer; robotic prostatectomy; staging.

MeSH terms

  • Aged
  • Algorithms*
  • Computer Graphics
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Organ Sparing Treatments
  • Peripheral Nerves / surgery*
  • Predictive Value of Tests
  • Prostate / pathology*
  • Prostatectomy / methods*
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery*
  • ROC Curve