Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28

M Kambouris; S R Dlouhy; J A Trofatter; P M Conneally; M E Hodes

doi:10.1002/ajmg.1320290138

Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28

Am J Med Genet. 1988 Jan;29(1):239-46. doi: 10.1002/ajmg.1320290138.

Authors

M Kambouris¹, S R Dlouhy, J A Trofatter, P M Conneally, M E Hodes

Affiliation

¹ Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223.

PMID: 2894172
DOI: 10.1002/ajmg.1320290138

Abstract

X-linked nephrogenic diabetes insipidus (NDI) was segregating in a large Indiana family. It was tested for linkage of the NDI gene to X-chromosome molecular markers. Maximum lod scores of 3.15 and 3.01 (theta = 0) obtained for the molecular markers F8A (F8C) and DXS15 (DX13) respectively, indicate that the NDI gene is located in Xq28. A lod score of 3.61 (theta = 0) was obtained with multipoint linkage analysis of F8A and DXS15.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Diabetes Insipidus / genetics*
Female
Genetic Markers
Glycosuria, Renal / genetics*
Humans
Lod Score
Male
Pedigree
Polymorphism, Restriction Fragment Length
X Chromosome*

Substances

Genetic Markers