Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis

Epilepsy Res. 2017 Nov:137:56-60. doi: 10.1016/j.eplepsyres.2017.09.012. Epub 2017 Sep 19.


This study aims to evaluate the overall prognosis, prognostic factors, and efficacy of treatment in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) who have access to third generation anti-epileptic drugs but not to epilepsy surgery. Eighty-five MTLE-HS patients were retrospectively placed into a seizure-free (seizure-free for >1year) or drug-resistant group, and the two groups were compared on the basis of age, sex, age at onset of seizures, duration of epilepsy, side of lesion, handedness, EEG findings, history of CNS infection, history of febrile convulsions, history of head trauma, history of cognitive impairment, family history of seizures, number of current anti-epileptic drugs (AEDs), total number of AED trials, and presence of individual AEDs. Only 24.7% of MTLE-HS patients had achieved seizure freedom for >1 year. Poor prognosis and drug-resistance were associated with younger age at onset of seizures (p=0.002), longer duration of epilepsy (p=0.018), greater number of current AEDs (p<0.001), and greater total number of AED trials (p<0.001). In addition, regimens with newer AEDs had no greater efficacy than regimens with older AEDs. Most medically managed MTLE-HS patients do not achieve seizure freedom despite multiple AED trials, and treatment with third generation AEDs should not preclude evaluation for epilepsy surgery.

Keywords: Anti-epileptic drugs; Epilepsy surgery; Hippocampal sclerosis; MRI; Natural history studies (prognosis).

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Anticonvulsants / therapeutic use*
  • Cross-Sectional Studies
  • Drug Resistant Epilepsy / drug therapy*
  • Drug Resistant Epilepsy / etiology
  • Drug Resistant Epilepsy / pathology
  • Drug Resistant Epilepsy / physiopathology
  • Drug Therapy, Combination
  • Epilepsy, Temporal Lobe / drug therapy*
  • Epilepsy, Temporal Lobe / etiology
  • Epilepsy, Temporal Lobe / pathology
  • Epilepsy, Temporal Lobe / physiopathology
  • Female
  • Hippocampus / pathology
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Regression Analysis
  • Retrospective Studies
  • Sclerosis
  • Young Adult


  • Anticonvulsants