Correlation of Tmax volumes with clinical outcome in anterior circulation stroke

Brain Behav. 2017 Jul 26;7(9):e00772. doi: 10.1002/brb3.772. eCollection 2017 Sep.


Background and purpose: The recent thrombectomy trials have shown that perfusion imaging is helpful in proper patient selection in thromboembolic stroke. In this study, we analyzed the correlation of pretreatment Tmax volumes in MR and CT perfusion with clinical outcome after thrombectomy.

Methods: Forty-one consecutive patients with middle cerebral artery occlusion (MCA) or carotid T occlusion treated with thrombectomy were included. Tmax volumes at delays of >4, 6, 8, and 10 s as well as infarct core and mismatch ratio were automatically estimated in preinterventional MRI or CT perfusion using RAPID software. These perfusion parameters were correlated with clinical outcome. Outcome was assessed using modified Rankin scale at 90 days.

Results: In patients with successful recanalization of MCA occlusion, Tmax > 8 and 10 s showed the best linear correlation with clinical outcome (r = 0.75; p = .0139 and r = 0.73; p = .0139), better than infarct core (r = 0.43; p = .2592). In terminal internal carotid artery occlusions, none of the perfusion parameters showed a significant correlation with clinical outcome.

Conclusions: Tmax at delays of >8 and 10 s is a good predictor for clinical outcome in MCA occlusions. In carotid T occlusion, however, Tmax volumes do not correlate with outcome.

Keywords: Tmax; outcome; perfusion; stroke; thrombectomy.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Infarction, Middle Cerebral Artery / diagnostic imaging*
  • Infarction, Middle Cerebral Artery / pathology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Perfusion Imaging / methods*
  • Prognosis
  • Retrospective Studies
  • Stroke / diagnostic imaging*
  • Stroke / pathology
  • Tomography, X-Ray Computed
  • Treatment Outcome