Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver

Biochemistry. 1987 Dec 15;26(25):8279-85. doi: 10.1021/bi00399a039.


Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706-1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5'-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Cytochrome P-450 Enzyme System / genetics*
  • DNA Restriction Enzymes
  • Genes*
  • Genes, Homeobox
  • Introns
  • Liver / metabolism*
  • Male
  • Molecular Sequence Data
  • Rats


  • Cytochrome P-450 Enzyme System
  • DNA Restriction Enzymes

Associated data

  • GENBANK/M18356
  • GENBANK/M18357
  • GENBANK/M18358
  • GENBANK/M18359
  • GENBANK/M18360
  • GENBANK/M18361
  • GENBANK/M18362
  • GENBANK/M18363